Adaptive Dynamics of Infectious Diseases: In Pursuit of Virulence Management
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An integrated study of the evolutionary ecology of infectious diseases and the management of virulent pathogens. Booknews Reports results from a research program on virulence management, sponsored by the International Institute for Applied Systems Analysis (IIASA), that explores the possibility of interfering with or even redirecting the evolution of virulence to achieve desired parasite goals. The 31 papers analyze the implications of host population structure for the evolution of virulence, the competition of pathogens within a host, pathogen-host coevolution, and multilevel selection. The final sections review the long-term effects of vaccines and drugs, and the options and problems of virulence management. Annotation c. Book News, Inc., Portland, OR
Contributing AuthorsList of BoxesNotational Standards1Introduction12Alternative Transmission Modes and the Evolution of Virulence103Wildlife Perspectives on the Evolution of Virulence264Adaptive Dynamics of Pathogen-Host Interactions395Dilemmas in Virulence Management606Variation in Susceptibility: Lessons from an Insect Virus747Contact Networks and the Evolution of Virulence858Virulence on the Edge: A Source-Sink Perspective1049Super- and Coinfection: The Two Extremes12410Super- and Coinfection: Filling the Range13811Multiple Infection and Its Consequences for Virulence Management15012Kin-selection Models as Evolutionary Explanations of Malaria16513Coevolution of Virus and Host Cell-death Signals18314Biogeographical Perspectives on Arms Races19715Major Histocompatibility Complex: Polymorphism from Coevolution21016Virulence Management and Disease Resistance in Diploid Hosts22217Coevolution in Gene-for-gene Systems23318Implications of Sexual Selection for Virulence Management24819Molecular Phylogenies and Virulence Evolution26220Weakened from Within: Intragenomic Conflict and Virulence28021Ecology and Evolution of Chestnut Blight Fungus28622Evolution of Exploitation and Defense in Tritrophic Interactions29723Managing Antibiotic Resistance: What Models Tell Us?32624Evolution of Vaccine-resistant Strains of Infectious Agents33925Pathogen Evolution: The Case of Malaria34726Vaccination and Serotype Replacement36227Taking Stock: Relating Theory to Experiment37928Virulence Management in Humans39929Virulence Management in Wildlife Populations41330Virulence Management in Veterinary Epidemiology42531Virulence Management in Plant-Pathogen Interactions43632Virulence Management in Biocontrol Agents44833Epilogue460References465Index515
