Antibodies Volume 2: Novel Technologies and Therapeutic Use
Volume 2: Novel Technologies and Therapeutic Use brings to the forefront current advances in novel technologies for the manufacturing of monoclonal antibodies and also their extensive clinical importance. Following on from Antibodies Volume 1: Production and Purification, this volume concentrates on:\ -new technologies in the manufacture of monoclonal antibodies,\ -the application of antibodies in cancer therapy and functional genomic therapy,\ -the importance of antibodies and prospects of...
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If the antibody industry is to achieve its full potential in the next decade, the individual technical potentials must be exploited, the limitations must be addressed, and lessons learned must be applied both to current purification methods and to the new technologies that continue to emerge. This book presents an overview of the current advances applied in the manufacture of monoclonal antibody including: -concepts in development of manufacturing strategies, -importance of antibody fragments, -application of chromatography method development, -quality control, -effect of expression on antibody properties, -virus removal and safety, -pharmacokinetics, -regulatory aspects. Antibodies Volume 1: Production and Purification together with Volume 2: Novel Technologies and Therapeutic Use will be of great value to all of those who are actively working in the field of antibodies. Volume 2: Novel Technologies and Therapeutic Use brings to the forefront current advances in novel technologies for the manufacturing of monoclonal antibodies and also their extensive clinical importance. Following on from Antibodies Volume 1: Production and Purification, this volume concentrates on: -new technologies in the manufacture of monoclonal antibodies, -the application of antibodies in cancer therapy and functional genomic therapy, -the importance of antibodies and prospects of antibody engineering for the future.
1Concepts in development of manufacturing strategies for monoclonal antibodies12Antibody fragments : production, purification and formatting for therapeutic applications253Large scale production of therapeutic antibodies : considerations for optimizing product capture and purification754Scale-up of antibody purification. From laboratory scale to production1015Purification of antibody of chromatographic methods1336Quality control of antibodies for human use1697Expression of human anti Rh(D) monoclonal antibodies into different cell lines : influence on their functional properties1898Monoclonal antibody production : minimising virus safety issues1999Contract manufacturing of biopharmaceutical grade antibodies22710The pharmacokinetics and pharmacodynamics of monoclonal antibodies24911Regulatory and legal requirements for the manufacture of antibodies275Index289
