Bacterial Pathogenesis: A Molecular Approach
Bacterial Pathogenesis: A Molecular Approach is the first text designed to provide a comprehensive introduction to this dynamic field for both students and researchers. The application of molecular techniques to the study of bacterium-host interaction has made possible great progress in fundamental understanding of the molecular basis of infectious diseases. In the text the authors integrate material from pathogenic microbiology, molecular biology, immunology, and human physiology to provide...
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The new edition of a textbook that places more emphasis than the first edition on recent research related to the genome maps of bacterium and the cell biology of the interaction between bacterial pathogens and host cells. After an introductory section detailing the broad outlines of the topic, including diagnosis and characterizations of bacterial infections, as well as various preventative strategies, the bulk of the work consists of chapters devoted to explaining specific bacterial pathogens. Pathogens discussed include the spirochetes, yersinia pestis, staphylococcus species, streptococci, enterococci, bordetella pertussis, anthrax, vibrio cholerae, and others. Annotation c. Book News, Inc., Portland, OR (booknews.com) Cynthia V. Sommer This textbook provides an understanding of the molecular mechanism involved in bacterial-host interactions that can produce infectious disease. Introductory chapters on host-parasite relationships are followed by discussions of well studied microorganisms that provide models of infectious disease. The purpose is to present recent advances on the role of bacteria in causing disease at the molecular level. The book integrates the genetics, biochemistry, cell biology, and immunology of bacterial pathogenesis. The authors meet their objective by providing a current textbook on molecular models of infectious diseases. This textbook is written for advanced undergraduate, graduate, and medical students interested in infectious disease. The book will be a useful resource for microbiologists and scientists from various disciplines. The clear writing style and didactic approach should meet the needs of the intended audience. The authors and the list of reviewers insure the accuracy and quality of the book. Each chapter includes an introductory outline, summary, selected readings, and questions that stimulate critical thinking. The adequate number of illustrations are clear and support the text. The boxed highlights, the organization and content of the text should stimulate the interest of the reader. The appendixes that include bacterial structure, detection methods, answers to chapter questions, and a glossary provide the tools and information for readers with various levels of knowledge. This is a thoughtful and well-written textbook for students and professionals interested in infectious disease. The book supports and strengthens the shift in thinking in the current scientific literature aboutinfectious diseases. This textbook fills a need for a current, concise molecular orientation to microbial pathogenesis .
PrefaceForewordPt. IBasic Principles1Ch. 1The Uneasy Truce: Never Underestimate the Power of Bacteria3Ch. 2Approaching and Studying Bacterial Diseases19Ch. 3Molecular Approaches to the Diagnosis and Characterization of Bacterial Infections34Ch. 4The First Line of Defense against Infection: Prevention and the Phagocytic Cell Response53Ch. 5The First Line of Defense, Continued: Complement, Chemokines, and Cytokines69Ch. 6The Second Line of Defense: Antibodies and Cytotoxic T Cells84Ch. 7Vaccination - an Underappreciated Component of the Modern Medical Armamentarium101Ch. 8Bacterial Strategies for Evading or Surviving the Defense Systems of the Human Body115Ch. 9Bacterial Exotoxins: Important but Still a Mystery131Ch. 10Antimicrobial Compounds150Ch. 11How Bacteria Become Resistant to Antibiotics168Pt. IISpecific Bacterial Pathogens185Ch. 12The Spirochetes: Borrelia burgdorferi and Treponema pallidum187Ch. 13Yersinia pestis, the Cause of Plague, and Its Relatives202Ch. 14Staphylococcus Species216Ch. 15Group A and Group B Streptococci and Enterococci232Ch. 16Pseudomonas aeruginosa and Related Species, a Lesson in Versatility247Ch. 17Bordetella pertussis263Ch. 18Streptococcus pneumoniae276Ch. 19Tuberculosis291Ch. 20Legionella pneumophila and Legionnaires' Disease311Ch. 21Mycoplasma pneumoniae and Chlamydia pneumoniae322Ch. 22Bacillus anthracis, the Cause of Anthrax332Ch. 23Helicobacter pylori, a Resourceful Gastric Pathogen339Ch. 24Clostridium difficile and Pseudomembranous Colitis352Ch. 25Vibrio cholerae, the Cause of Cholera363Ch. 26Salmonella Species381Ch. 27Listeria monocytogenes, a Doubly Motile Pathogen398Ch. 28Diarrheagenic Escherichia coli Strains407Ch. 29Escherichia coli Extraintestinal Infections422Ch. 30Neisseria Species437Ch. 31Chlamydia trachomatis452App. 1Overview of Bacterial Secretion Systems, Bacterial Adhesins and Their Mechanisms of Assembly, and Major Bacterial Toxins461App. 2: Answers to End-of-Chapter Questions467
\ Cynthia V. SommerThis textbook provides an understanding of the molecular mechanism involved in bacterial-host interactions that can produce infectious disease. Introductory chapters on host-parasite relationships are followed by discussions of well studied microorganisms that provide models of infectious disease. The purpose is to present recent advances on the role of bacteria in causing disease at the molecular level. The book integrates the genetics, biochemistry, cell biology, and immunology of bacterial pathogenesis. The authors meet their objective by providing a current textbook on molecular models of infectious diseases. This textbook is written for advanced undergraduate, graduate, and medical students interested in infectious disease. The book will be a useful resource for microbiologists and scientists from various disciplines. The clear writing style and didactic approach should meet the needs of the intended audience. The authors and the list of reviewers insure the accuracy and quality of the book. Each chapter includes an introductory outline, summary, selected readings, and questions that stimulate critical thinking. The adequate number of illustrations are clear and support the text. The boxed highlights, the organization and content of the text should stimulate the interest of the reader. The appendixes that include bacterial structure, detection methods, answers to chapter questions, and a glossary provide the tools and information for readers with various levels of knowledge. This is a thoughtful and well-written textbook for students and professionals interested in infectious disease. The book supports and strengthens the shift in thinking in the current scientific literature aboutinfectious diseases. This textbook fills a need for a current, concise molecular orientation to microbial pathogenesis .\ \ \ \ \ BooknewsA comprehensive introduction to the study of bacterium-host interaction, and to progress and challenges in the understanding of the molecular basis of infectious diseases. Integrates material from pathogenic microbiology, molecular biology, immunology, and human physiology. Annotation c. Book News, Inc., Portland, OR booknews.com\ \ \ From The CriticsReviewer: Cynthia V. Sommer, PhD(University of Wisconsin-Milwaukee)\ Description: This textbook provides an understanding of the molecular mechanism involved in bacterial-host interactions that can produce infectious disease. Introductory chapters on host-parasite relationships are followed by discussions of well studied microorganisms that provide models of infectious disease.\ Purpose: The purpose is to present recent advances on the role of bacteria in causing disease at the molecular level. The book integrates the genetics, biochemistry, cell biology, and immunology of bacterial pathogenesis. The authors meet their objective by providing a current textbook on molecular models of infectious diseases.\ Audience: This textbook is written for advanced undergraduate, graduate, and medical students interested in infectious disease. The book will be a useful resource for microbiologists and scientists from various disciplines. The clear writing style and didactic approach should meet the needs of the intended audience. The authors and the list of reviewers insure the accuracy and quality of the book.\ Features: Each chapter includes an introductory outline, summary, selected readings, and questions that stimulate critical thinking. The adequate number of illustrations are clear and support the text. The boxed highlights, the organization and content of the text should stimulate the interest of the reader. The appendixes that include bacterial structure, detection methods, answers to chapter questions, and a glossary provide the tools and information for readers with various levels of knowledge.\ Assessment: This is a thoughtful and well-written textbook for students and professionals interested in infectious disease. The book supports and strengthens the shift in thinking in the current scientific literature about infectious diseases. This textbook fills a need for a current, concise molecular orientation to microbial pathogenesis .\ \ \ \ \ 3 Stars from Doody\ \
