Biography of a Germ
Arno Karlen, author of Man and Microbes, focuses on a single bacterium in Biography of a Germ, giving us an intimate view of a life that has been shaped by and is in turn transforming our own.\ Borrelia burgdorferi is the germ that causes Lyme disease. In existence for some hundred million years, it was discovered only recently. Exploring its evolution, its daily existence, and its journey from ticks to mice to deer to humans, Karlen lucidly examines the life and world of this recently...
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Biography of a Germ (Pantheon Books/May 30, 2000/$22) by Arno Karlen is the first book about the fascinating and dangerous bacterium that causes Lyme disease. Karlen tells the amazing life story of borellia burgdorferi–called Bb for short–the spiral bacterium behind Lyme disease, yet unlike any previous books about microbes in general, he tells the story from the germ's point of view. Karlen takes the reader on voyage through the germ's life cycle, a trip more ingenious than any science fiction. Bb has been around for hundreds of millions of years, and will, Karlen informs us, outlive the human species. For Bb, life is esentially the endless search for a home, or host. Bb's relationship with its hosts are so specialized that it must first reside in three different creatures–deer tick, mouse, and deer–only in that order, befiore it enters a human. In Biology of a Germ, Karlen describes in vivid detail the life and times of Bb's favorite host, the deer tick. From the tick's eating and growth patterns ("blood meals") and sexual behavior (both disgusting and fascinating, we learn) to their mobility problems ("no wings, cannot jump, and walks like a nonagenarian"), and how they solve those dilemmas, Karlen reveals a creature of astounding tenacity and adaptability. Karlen relates two milestones in the germ's history–the discovery of Lyme disease in 1977 and of Bb itself in 1982 by Swiss scientist Billy Burgdorfer. He continues to show how Bb and humans, which coexisted for millions of years on earth without meeting, became entangled. It ocurred, Karlen explains, because people changed their habits, technology and use of land, transforming their environment. Consequently, Bb now thrives worldwide from Lyme, CT to Europe, China, and Austrailia, in hundreds of species. Karlen has written a number of books on history and science in the past. With his latest, he gives us a winning combination of great science writing and a truly etertaining narrative. About the Author: Arno Karlen, Ph.D., a psychoanalyst, has written widely on history and biomedical science. He is the author of Napolean's Glands and Other Ventures in Biohistory and Man and Microbes: Diseases and Plagues in History and Modern Times. He lives in New York City. Publishers Weekly The germ is Borrelia burgdorferi, Bb for short, and causes Lyme disease in the people it infects: before it hits a human, Bb has to reside in three other animals--a mouse, a tick and a deer, in that order. This odd property, and the germ's wide distribution, means that Bb has been affected by changes in human land use--factories, clear-cuts, the growth of the suburbs and the environmental movement all had to happen for Lyme to become something Americans think about. And think about it we do: Bb is now so interesting that in 1997 scientists mapped its genome. All these facets make Bb the ideal candidate for what Karlen (Man and Microbes, etc.) claims is the first history of a pathogen written from that pathogen's perspective. Fascinating in their own right, Bb and its relatives also demonstrate larger patterns and questions in the study and history of microbes and molecular biology, of zoology and ecology, of medicine, public health policy and disease. In 22 brief chapters, Karlen lays out and answers some of those questions. He tells of Bb's sibling spirochetes, which cause syphilis and tropical diseases. He explains how ticks' adaptations let them parasitize "a chipmunk or a human," "a wren or a raccoon," and how Bb's adaptations let it jump between ticks and their hosts. Karlen has created a vigorous, compact account of Bb's life and times. And beyond the zoology and disease control, Karlen even offers a message: "Pathogens... are just trying to survive, and sometimes they must do so at other creatures' expense." The same could be said of humans." (June) Copyright 2000 Cahners Business Information.\|
Chapter One: A Very Small Life\ To the naked eye, it is invisible, a nothing. Under the microscope, it seems a silvery corkscrew undulating on a dark field. The form has simple elegance, like the whorl of a nautilus shell or the sweep of a dragonfly wing. But that simplicity is an illusion. Through the more powerful electron microscope you see not a featureless wiggle but a shape-shifter — now a spiral, now a thread, now a rod or a sphere — with two walls, a dozen whiplike appendages and internal structures. And beyond any microscope's view, revealed only indirectly, by laboratory tests, lies a marvel of complexities. The surface bristles with molecules that sense and respond to the environment, and the interior churns like a chemical factory. Inside, more than a thousand genes flicker on and off in changing sequences, to allow survival in places as different as a tick's gut, a dog's knee and a human brain.\ It is the bacterium Borrelia burgdorferi, by human standards a very small, brief flicker of life. Yet the boldest writer of science fiction could not invent a creature so ingenious, whose existence is entwined with that of so many other species. Although this microbe inhabits much of the earth and myriad hosts, it was not discovered until 1982, and then only because it had ignited a new epidemic, Lyme disease. That illness, so troubling to humans, is just a short, recent chapter in the germ's long history, and from its own perspective not the most important one. Borrelia burgdorferi has an ancient lineage, far older than ours, and despite all the vaccines and antibiotics we devise, it has a more promising future. It preceded people on earth and will doubtless survive us. For that reason alone it deserves respectful biographers.\ Clearly there is much drama in this little theater. But that should be no surprise, for just as every person's life, seen close up, is compelling, so is every other creature's. Borrelia burgdorferi is proof that if you want to see life afresh and be struck with awe, you need only take a germ's-eye view of the world.
1A Very Small Life32A Subject Not Picked at Random53A Brief Aside Touching the Erotic Flea124Why Bb in Particular165Apologia Pro Vita Sua: In Defense of Germs216In Some Warm Little Pond347Linnaeus's Tree448And Bb's Twig529Gaia, or Nearly Everyone's Cousin6010Very Small Indeed6411Not Just a Corkscrew7312A Possibly Poignant Anatomy7613Instead of Sex8314A Fantastic Voyage8715Equally Fantastic9716Is the Tick Sick?10517Rash Discoveries11118The Magic of Names11719The Annals of Myopia12120From Bitterroot to Lyme12621Far from Primeval13322Machupo and Other Disturbances14523With Apologies of Sorts15324Like Darwin's Finches?16325A More Hopeful Future171
\ Publishers Weekly\ - Publisher's Weekly\ The germ is Borrelia burgdorferi, Bb for short, and causes Lyme disease in the people it infects: before it hits a human, Bb has to reside in three other animals--a mouse, a tick and a deer, in that order. This odd property, and the germ's wide distribution, means that Bb has been affected by changes in human land use--factories, clear-cuts, the growth of the suburbs and the environmental movement all had to happen for Lyme to become something Americans think about. And think about it we do: Bb is now so interesting that in 1997 scientists mapped its genome. All these facets make Bb the ideal candidate for what Karlen (Man and Microbes, etc.) claims is the first history of a pathogen written from that pathogen's perspective. Fascinating in their own right, Bb and its relatives also demonstrate larger patterns and questions in the study and history of microbes and molecular biology, of zoology and ecology, of medicine, public health policy and disease. In 22 brief chapters, Karlen lays out and answers some of those questions. He tells of Bb's sibling spirochetes, which cause syphilis and tropical diseases. He explains how ticks' adaptations let them parasitize "a chipmunk or a human," "a wren or a raccoon," and how Bb's adaptations let it jump between ticks and their hosts. Karlen has created a vigorous, compact account of Bb's life and times. And beyond the zoology and disease control, Karlen even offers a message: "Pathogens... are just trying to survive, and sometimes they must do so at other creatures' expense." The same could be said of humans." (June) Copyright 2000 Cahners Business Information.\|\ \ \ \ \ Library JournalThe story of Borrelia burgdorferi (Bb), the microorganism that causes Lyme disease, should interest a wide audience, especially in North America, where much of the narrative unfolds. Psychoanalyst Karlen has a predilection for the social history of disease (his other books include Napoleon's Glands and Other Ventures in Biohistory; Man and Microbes: Disease and Plagues in History and Modern Times). Here, the author traces the social and environmental changes that might have caused the spread of Lyme disease. The early chapters are particularly well done, especially "Apologia pro vita sua," a spirited defense of the microbial world. As it is written for the general reader, the text would have benefited from additional illustrations to reinforce complicated details, such as Bb's life cycle, in the minds of readers. Suitable for all public libraries.--Leila Fernandez, Steacie Science Lib., York Univ,, Toronto Copyright 2000 Cahners Business Information.\\\ \ \ BooknewsKarlan, a psychoanalyst who has written several books on history and biomedical science, delves into the evolution and day-to-day life of Borrelia burgdorferi (Bb), the germ that causes Lyme disease, from the germ's point of view. An index and some sort of reference list would have proved useful. Readers explore Bb's life cycle, its search for a host, and its relationships with these hosts, including humans. Annotation c. Book News, Inc., Portland, OR (booknews.com)\ \ \ \ \ Bernstein[An] informative and clever little book...when he gets to Bb itself, Mr. Karlen's book becomes informative and entertaining at the same time, a fine piece of popular science writing that covers the biological basics for those who do not know them but covers them stylishly enough for the more informed to gain insight, too. \ —The New York Times\ \ \ \ \ Malcolm FarleyArno Karlen has written a charming profile of a distinctly uncharming microorganism: Borrelia burgdorferi (or Bb), the bacterium that causes Lyme disease...Biography of a Germ is more than an elegant detour through the back roads of microbial ecology. \ —The New York Times Book Review\ \
