Biomedical Applications of Light Scattering
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Essential light scattering theories, techniques, and practicesExtend tissue characterization and analysis capabilities using cutting-edge biophotonics tools and technologies. This comprehensive resource details the principles, devices, and procedures necessary to fully employ light scattering in clinical and diagnostic applications. Biomedical Applications of Light Scattering explains how to work with biological scatterers and scattering codes, accurately model tissues and cells, build time-domain simulations, and resolve inverse scattering issues. Noninvasive biopsy procedures, precancer and disease screening methods, and fiber optic probe design techniques are also covered in this detailed volume. Analyze light scattering spectra from complex and continuous mediaBuild high-resolution cellular models using FDTD and PSTD methodsWork with confocal microscopic imaging and diffuse optical tomographyMeasure blood flow using laser Doppler, LSCI, and photon correlation Perform noninvasive optical biopsies using elastic scattering techniques Assess bulk tissue properties using differential pathlength spectroscopyDetect precancerous lesions using angle-resolved low-coherence interferometryRisk-stratify patients for colonoscopies using enhanced backscattering methods
Pt. 1 Introduction to Light Scattering Models1 Classical Light Scattering Models 32 Light Scattering from Continuous Random Media 313 Modeling of Light Scattering by Biological Tissues Via Computational Solution of Maxwell's Equations 494 Interferometric Synthetic Aperture Microscopy 77Pt. 2 Application to In Vitro Cell Biology5 Light Scattering as a Tool in Cell Biology 1156 Light Absorption and Scattering Spectroscopic Microscopies 143Pt. 3 Assessing Bulk Tissue Properties from Scattering Measurements7 Light Scattering in Confocal Reflectance Microscopy 1718 Tissue Ultrastructure Scattering with Near-Infrared Spectroscopy: Ex Vivo and In Vivo Interpretation 193Pt. 4 Dynamic Light Scattering Methods9 Dynamic Light Scattering and Motility-Contrast Imaging of Living Tissue 21310 Laser Speckle Contrast Imaging of Blood Flow 241Pt. 5 Clinical Applications11 Elastic-Scattering Spectroscopy for Optical Biopsy: Probe Designs and Analytical Methods for Clinical Applications 26312 Differential Pathlength Spectroscopy 29313 Angle-Resolved Low-Coherence Interferometry: Depth-Resolved Light Scattering for Detecting Neoplasia 31314 Enhanced Backscattering and Low-Coherence Enhanced Backscattering Spectroscopy 341Index 361
