Horizontal Gene Transfer in the Evolution of Pathogenesis

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Author: Michael Hensel

ISBN-10: 0521862973

ISBN-13: 9780521862974

Category: Basic Sciences

Horizontal gene transfer is a major driving force in the evolution of many bacterial pathogens. The development of high-throughput sequencing tools and more sophisticated genomic and proteomic techniques in recent years has resulted in a better understanding of this phenomenon. Written by leading experts in the field, this edited volume is aimed at graduate students and researchers and provides an overview of current knowledge relating to the evolution of microbial pathogenicity. This volume...

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Overview of mechanisms and biological consequences of horizontal gene transfer in the evolution of pathogenicity.

Part I. Theoretical Considerations on the Evolution of Bacterial Pathogens:1. Genomes in motion - gene transfer as a catalyst for genome change Jeffrey G. Lawrence and Heather Hendrickson; 2. Bacterial recombination in vivo Xavier Didelot and Daniel Falush; Part II. Mobile Genetic Elements in Bacterial Evolution: 3. Phage-bacterium co-evolution and its implication for bacterial pathogenesis Harald Brüssow; 4. Phage conversion - driving forces in the development and spread of bacterial pathogens Roger W. Hendrix and Sherwood R. Casjens; 5. Genomic islands in the bacterial chromosome - paradigms of microevolution in quantum leaps Tobias Ölschläger and Jörg Hacker; Part III. Paradigms of Bacterial Evolution: 6. Genomic islands in plant-pathogenic bacteria Dawn L. Arnold and Robert W. Jackson; 7. Prophage contribution to salmonella virulence and diversity Sébastien Lemire, Nara Figueroa-Bossi and Lionello Bossi; 8. Pathogenic yersiniae: stepwise gain of virulence due to sequential acquisition of mobile genetic elements Elisabeth Carniel; 9. Genomic or pathogenicity islands in streptococcus pneumoniae Barbara Albiger, Christel Blomberg, Jessica Dagerhamm, Staffan Normark and Brigitta Henriques-Normark; 10. The mobile genetic elements of staphylococcus aureus Richard P. Novick; 11. Influence of human lifestyle on dissemination of transferable elements Wolfgang Witte; Part IV. Interkingdom Transfer and Endosymbiosis: 12. Eukaryotic gene transfer: adaptation and replacements Jan O. Andersson; 13. Lessons in evolution from genome reduction in bacterial endosymbionts AndrésMoya and Amparo Latorre.