Ion Channels of Excitable Membranes
Ion channels are macromolecular pores in cell membranes. Bertil (University of Washington) describes the known ion channels and their physiological functions, then develops the physical and molecular principles behind permeation, gating, pharmacological modification, and molecular diversity. The third edition adds chapters on calcium signaling, structural biology, and molecular biology and genomics. \ Annotation c. Book News, Inc., Portland, OR (booknews.com)\ \ \...
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Ion channels are macromolecular pores in cell membranes. Bertil (University of Washington) describes the known ion channels and their physiological functions, then develops the physical and molecular principles behind permeation, gating, pharmacological modification, and molecular diversity. The third edition adds chapters on calcium signaling, structural biology, and molecular biology and genomics. Annotation c. Book News, Inc., Portland, OR (booknews.com) Booknews Discusses the classic biophysical work of Hodgkin and Huxley, weaves a description of the known ionic channels together with their biological functions, and then develops the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, molecular diversity, and channel evolution. Includes new chapters on fast chemical synapses, modulation through G protein- coupled receptors and second messenger systems, molecular cloning, site-directed mutagenesis, and cell biology. Annotation c. Book News, Inc., Portland, OR (booknews.com)
Ch. 1Introduction1Pt. IDescription of ChannelsCh. 2Classical Biophysics of the Squid Giant Axon25Ch. 3The Superfamily of Voltage-Gated Channels61Ch. 4Voltage-Gated Calcium Channels95Ch. 5Potassium Channels and Chloride Channels131Ch. 6Ligand-Gated Channels of Fast Chemical Synapses169Ch. 7Modulation, Slow Synaptic Action, and Second Messengers201Ch. 8Sensory Transduction and Excitable Cells237Ch. 9Calcium Dynamics, Epithelial Transport, and Intercellular Coupling269Pt. IIPrinciples and Mechanisms of FunctionCh. 10Elementary Properties of Ions in Solution309Ch. 11Elementary Properties of Pores347Ch. 12Counting Channels and Measuring Fluctuations377Ch. 13Structure of Channel Proteins405Ch. 14Selective Permeability: Independence441Ch. 15Selective Permeability: Saturation and Binding471Ch. 16Classical Mechanisms of Block503Ch. 17Structure-Function Studies of Permeation and Block539Ch. 18Gating Mechanisms: Kinetic Thinking575Ch. 19Gating: Voltage Sensing and Inactivation603Ch. 20Modification of Gating in Voltage-Sensitive Channels635Ch. 21Cell Biology and Channels663Ch. 22Evolution and Origins693References723Index788
\ BooknewsDiscusses the classic biophysical work of Hodgkin and Huxley, weaves a description of the known ionic channels together with their biological functions, and then develops the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, molecular diversity, and channel evolution. Includes new chapters on fast chemical synapses, modulation through G protein- coupled receptors and second messenger systems, molecular cloning, site-directed mutagenesis, and cell biology. Annotation c. Book News, Inc., Portland, OR (booknews.com)\ \
