Mass Spectrometry in Drug Metabolism and Pharmacokinetics
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Advanced mass spectrometry techniques to support your drug discovery and development researchInside this book are a host of practical tools and techniques that enable you to fully leverage the capabilities of mass spectrometry in order to get the most out of drug metabolism and pharmacokinetics studies. You'll learn the latest applications for determining how a drug is absorbed, distributed, metabolized, and excreted by the body.Logically organized, Mass Spectrometry in Drug Metabolism and Pharmacokinetics starts off with an overview of the role of mass spectrometry in drug discovery and development. It then shows you how to perform routine applications before introducing you to sophisticated tools and techniques for solving complex drug metabolism and pharmacokinetics problems. Throughout the book, the main focus is on the use of LC-MS and MALDI-MS.Each chapter has been written by one or more leading experts who share their own first-hand laboratory experience. You'll gain a wealth of tips for performing successful analyses as well as avoiding common pitfalls. Moreover, the book is packed with features that help you grasp new concepts quickly and put your knowledge into practice, including:Figures and illustrations to help you understand how to perform specific techniques and applicationsCharts and tables that serve as quick summaries and reference guidesCoverage of the latest tested-and-proven techniquesReferences leading to the primary literature in the fieldCarefully edited to ensure thoroughness and a uniform standard of quality, this book is sure to help you advance your own important drug research efforts. Doody Review Services Reviewer:Xiaochao Ma, PhD(University of Kansas Medical Center)Description:This practical book covers the latest applications of mass spectrometry in drug absorption, distribution, metabolism, and excretion. The authors are experts in the fields of drug metabolism and pharmacokinetics from pharmaceutical companies, instrumental corporations, and universities.Purpose:The purpose is to provide comprehensive information about mass spectrometry for solving complex problems in chemical analysis.Audience:This book is valuable for scientists working in academic, industrial, and healthcare-related fields, who use mass spectrometry to investigate drug metabolism and pharmacokinetics, chemical markers of toxicity and disease, xenobiotic exposure, and so on.Features:The 12 chapters can be characterized in one of three ways: 1) introducing the knowledge of mass spectrometry from the simple basics to the complex applications; 2) combining mass spectrometry techniques with the applications in drug metabolism and pharmacokinetics; 3) sharing of first-hand laboratory experience from leading experts around the world. The book begins with an overview of mass spectrometry in drug discovery and development and then details the applications of mass spectrometry in metabolites screening, identification, and quantification.Assessment:In comparison to other books on mass spectrometry, this one not only provides both the basic and latest knowledge in mass spectrometry, but integrates the theory with applications to drug metabolism and pharmacokinetics. For instance, chapter 4, on the applications of quandrupole time-of- flight (Q-TOF) mass spectrometry in reactive metabolites screening, demonstrates the importance of exact mass measurements and high-resolution mass spectrometry in metabolites screening and identification. This chapter also introduces the MetaboLynx software, which could facilitate the identification of metabolites. This knowledge is very helpful for scientists in the metabolomic field.
1 Evolving Role of Mass Spectrometry in Drug Discovery and Development Dil M. Ramanathan Ramanathan, Dil M. Richard M. LeLacheur LeLacheur, Richard M. 12 Quantitative Bioanalysis in Drug Discovery and Development: Principles and Applications Ayman El-Kattan El-Kattan, Ayman Chris Holliman Holliman, Chris Lucinda H. Cohen Cohen, Lucinda H. 873 Quadrupole, Triple-Quadrupole, and Hybrid Linear Ion Trap Mass Spectrometers for Metabolite Analysis Elliott B. Jones Jones, Elliott B. 1234 Applications of Quadrupole Time-of-Flight Mass Spectrometry in Reactive Metabolite Screening Jose M. Castro-Perez Castro-Perez, Jose M. 1595 Changing Role of FTMS in Drug Metabolism Petia A. Shipkova Shipkova, Petia A. Jonathan L. Josephs Josephs, Jonathan L. Mark Sanders Sanders, Mark 1916 High-Resolution LC-MS-Based Mass Defect Filter Approach: Basic Concept and Application in Metabolite Detection Haiying Zhang Zhang, Haiying Donglu Zhang Zhang, Donglu Mingshe Zhu Zhu, Mingshe Kenneth L. Ray Ray, Kenneth L. 2237 Applications of High-Sensitivity Mass Spectrometry and Radioactivity Detection Techniques in Drug Metabolism Studies Wing W. Lam Lam, Wing W. Cho-Ming Loi Loi, Cho-Ming Angus Nedderman Nedderman, Angus Don Walker Walker, Don 2538 Online Electrochemical-LC-MS Techniques for Profiling and Characterizing Metabolites and Degradants Paul H. Gamache Gamache, Paul H. David F. Meyer Meyer, David F. Michael C. Granger Granger, Michael C. Ian N. Acworth Acworth, Ian N. 2759 LC-MS Methods with Hydrogen/Deuterium Exchange for Identification of Hydroxylamine, N-Oxide, and Hydroxylated Analogs of Desloratadine Natalia A. Penner Penner, Natalia A. Joanna Zgoda-Pols Zgoda-Pols, JoannaRagu Ramanathan Ramanathan, Ragu Swapan K. Chowdhury Chowdhury, Swapan K. Kevin B. Alton Alton, Kevin B. 29510 Turbulent-Flow LC-MS: Applications for Accelerating Pharmacokinetic Profiling and Metabolite Identification Joseph L. Herman Herman, Joseph L. Joseph M. Di Bussolo Di Bussolo, Joseph M. 31111 Desorption Ionization Techniques for Quantitative Analysis of Drug Molecules Jason S. Gobey Gobey, Jason S. John Janiszewski Janiszewski, John Mark J. Cole Cole, Mark J. 34112 MALDI Imaging Mass Spectrometry for Direct Tissue Analysis of Pharmaceuticals Yunsheng Hsieh Hsieh, Yunsheng Walter A. Korfmacher Korfmacher, Walter A. 359Index 383
