Molecules and Medicine
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Molecules and Medicine provides, for the first time ever, a completely integrated look at chemistry, biology, drug discovery, and medicine. It delves into the discovery, application, and mode of action of more than one hundred of the most significant molecules in use in modern medicine. Opening sections of the book provide a unique, clear, and concise introduction, which enables readers to understand chemical formulas. Doody Review Services Reviewer:Eugene A Davidson, PhD(Georgetown University School of Medicine)Description:This is a picture book with explanations -- various drugs are shown together with a superficial discussion of their application.Purpose:The goal is to introduce molecules to the interested student. The hook is the medical utility of the representatives chosen, but the value of this is questionable and it is not clear that the goal is achieved.Audience:The intended audience is undergraduate students with some passing interest in how drugs might work. Most lay readers could follow the text as well. One of the authors is a world class authority.Features:This is basically a picture book of commonly used drugs, presenting structural and computer-derived space-filling formulas, divided into classes by their medical applications. In each target, some brief description of possible mode of action is provided. Some of the material is out of date and the choice of drugs seems entirely arbitrary (why lipitor, for example, as the only statin drug?). Statements like "Chemistry can cure disease," while true in some circumstances, are clearly hyperbole. References are provided for each of the compounds. A serious concern is that uninitiated readers (the target audience) will acquire a very superficial and possibly misleading set of facts about one or another commercial product. "A little learning is a dangerous thing," as Alexander Pope notably stated. Physics for poets may have its place, but science deserves better.Assessment:This effort cannot be recommended since it is overly superficial.
PART I. INTRODUCTION. UNDERSTANDING STRUCTURAL DIAGRAMS OF ORGANIC MOLECULES. SOME COMMON MOLECULES. PROTEINS AND THREE-DIMENSIONAL PROTEIN STRUCTURE. SOME OF THE PROTEIN STRUCTURES THAT APPEAR IN THIS BOOK. PART II. INFLAMMATORY, CARDIOVASCULAR AND METABOLIC DISEASES. ANTI-INFLAMMATORY AGENTS. Acetylsalicylic acid Aspirin). Naproxen (Aleve). How Do Anti-Inflammatory Drugs Work? Other Eicosanoids in Inflammation. An Overview of Inflammation. Celecoxib (Celebrex). Prednisone (Deltasone). Methotrexate (Trexall). Allopurinol (Zyloprim). ANTIASTHMATIC AND ANTIALLERGIC AGENTS. Salmeterol (Serevent). Fluticasone Propionate (Flovent). Montelukast Sodium (Singulair). Tiotropium Bromide (Spiriva). Loratadine (Claritin). TYPE 2 DIABETES. An Overview of Metabolic Syndrome. ANTIDIABETIC AND CHOLESTEROL-LOWERING AGENTS. Metformin (Glucophage). Glipizide (Glucotrol). Pioglitazone (Actos). Sitagliptin (Januvia). Atorvastatin (Lipitor). Ezetimibe (Zetia). CARDIOVASCULAR AGENTS. Atenolol (Tenormin). Enalapril (Vasotec). Candesartan Cilexetil (Atacand). Aliskiren (Tekturna). Amlodipine (Norvasc). Nitroglycerin. Clopidogrel Bisulfate (Plavix). Digoxin (Lanoxin). RECEPTORS AND SIGNALING. Information Flow into the Cell by Chemical Signaling. REFERENCES FOR PART II. PART III. REPRODUCTIVE MEDICINE. Oral Contraceptives. Testosterone. Mifepristone (Mifeprex). Oxytocin (Oxytocin). Sildenafil (Viagra). OSTEOPOROSIS. Some Aspects of Osteoporosis. Alendronate (Fosamax). Calcitriol (Rocaltrol). Raloxifene (Evista). Teriparatide (Forteo). GLAUCOMA AND ANTIULCER AGENTS. Latanoprost (Xalatan). Ranitidine (Zantac). Omeprazole (Prilosec). REFERENCES FOR PART III. PART IV. AUTOIMMUNE DISEASE AND ORGAN TRANSPLANT. A Brief Survey of the Immune System. IMMUNOSUPPRESSIVE AGENTS. Azathioprine (Imuran). Mycophenolate Mofetil (CellCept). Cyclosporin (Neoral). Tacrolimus (Prograf). FTY720 (Fingolimod). INFECTIOUS DISEASES. ANTIBIOTICS. Amoxicillin (Amoxil). Cefaclor (Ceclor). Doxycycline (Vibramycin). Azithromycin (Zithromax). Ciprofloxacin (Cipro). Trimethoprim (Triprim). Amikacin (Amikin). Vancomycin (Vancocin). Linezolid (Zyvox). Isoniazid (Laniazid). Ancillary Antibiotics. Drug Resistance. ANTIVIRAL AGENTS. On Viruses and Viral Diseases. Acyclovir (Zovirax). Ribavirin (Virazole). Oseltamivir (Tamiflu). Zidovudine (Retrovir, AZT). Zalcitabine (Hivid). Nevirapine (Viramune). Efavirenz (Sustiva). Lopinavir + Ritonavir (Kaletra). UK427857 (Maraviroc). ANTIFUNGAL AGENTS. Amphotericin (Fungizone). Fluconazole (Diflucan). Caspofungin (Cancidas). Terbinafine (Lamisil). ANTIMALARIAL AND ANTIPARASITIC AGENTS. Parasitic Diseases: A Focus on Malaria. Chloroquine (Aralen). Artemether + Lumefantrine (CoArtem). Atovaquone + Proguanil (Malarone). Miltefosine (Impavido). Nitazoxanide (Alinia). Ivermectin (Stromectol). REFERENCES FOR PART IV. PART V. MALIGNANT DISEASE. An Overview of Cancer. Capecitabine (Xeloda). Carboplatin (Paraplatin). Vinblastine (Velban). Paclitaxel (Taxol). Cyclophosphamide (Cytoxan). Tamoxifen (Nolvadex). Irinotecan (Camptosar). Bleomycin (Blenoxane). Imatinib (Gleevec). Sunitinib (Sutent). Bortezomib (Velcade). Ancillary Anticancer Agents. REFERENCES FOR PART V. PART VI. DRUGS ACTING ON THE NERVOUS SYSTEM. PAIN AND ANALGESIA. Lidocaine (Xylocaine). Morphine (Avinza). Acetaminophen (Tylenol). Fentanyl (Duragesic). Sodium Thiopental (Sodium Pentothal). Gabapentin (Neurontin). Diazepam (Valium). Sumatriptan (Imitrex). HYPNOTICS (INSOMNIA) AND ANTISMOKING. Zolpidem (Ambien). Ramelteon (Rozerem). Varenicline (Chantix). The Brain, Neurotransmission and Molecular Neurotransmitters. NEURODEGENERATIVE AND PSYCHIATRIC DISEASES. Levodopa (Larodopa). Donepezil (Aricept). ANTIEPILEPTIC AGENTS. ANTIANXIETY AGENTS. ANTIDEPRESSANTS. ANTIPSYCHOTICS. REFERENCES FOR PART VI. GLOSSARY. INDEX.
