Nonneutral Evolution
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All organisms—from the AIDS virus, to bacteria, to fish, to humans—must evolve to survive. Despite the central place of evolution within biology, there are many things that are still poorly understood. For Charles Darwin, the driving force behind all evolution was natural selection. More recently, evolutionary biologists have considered that many mutations are essentially neutral with respect to natural selection. Many questions remain. Are molecular differences between species adaptive? Are differences within species adaptive? Modern biotechnology has enabled us to identify precisely the actual DNA structure from many individuals within a population, and thus to see how these DNA sequences have changed over time and to answer some of these questions. At the same time, this knowledge poses new challenges to our ability to understand the observed patterns. This exciting volume outlines the biological problems, provides new perspectives on theoretical treatments of the consequences of natural selection, examines the consequences of molecular data, and relates molecular events to speciation. Every evolutionary biologist will find it of interest.
PrefaceContributors1Alternatives to the Neutral Theory12Patterns of Polymorphism and Between Species Divergence in the Enzymes of Central Metabolism183Molecular Population Genetics in Drosophila pseudoobscura: Three Future Directions294Selection, Recombination, and DNA Polymorphism in Drosophila465Effects of Genetic Recombination and Population Subdivision on Nucleotide Sequence Variation in Drosophila ananassae576Polymorphism and Divergence in Regions of Low Recombination in Drosophila677Inferring Selection and Mutation from DNA Sequences: The McDonald-Kreitman Test Revisited778Detecting Natural Selection by Comparing Geographic Variation in Protein and DNA Polymorphisms889A Neutrality Test for Continuous Characters Based on Levels of Intraspecific Variation and Interspecific Divergence10110Estimation of Population Parameters and Detection of Natural Selection from DNA Sequences11211Using Maximum Likelihood to Infer Selection from Phylogenies12612Gene Trees with Background Selection14013Phylogenetic Analysis on the Edge: The Application of Cladistic Techniques at the Population Level15414The Divergence of Halophilic Superoxide Dismutase Gene Sequences: Molecular Adaptation to High Salt Environments17515Mitochondrial Haplotype Frequencies in Oysters: Neutral Alternatives to Selection Models18816Gene Duplication, Gene Conversion and Codon Bias19917Genealogical Portraits of Speciation in the Drosophila melanogaster Species Complex20818Genetic Divergence, Reproductive Isolation and Speciation21719Polymorphism at Mhc Loci and Isolation by the Immune System in Vertebrates233Index247
