Oral Pharmacotherapy for Male Sexual Dysfunction: A Guide to Clinical Management
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With the advent of such oral drugs as Viagra®, Cialis®, and Levitra® for the treatment of erectile dysfunction (ED), the burden of first patient evaluation has fallen on the primary care provider. In Oral Pharmacotherapy for Male Sexual Dysfunction: A Guide to Clinical Management, highly experienced urologists and physician researchers review each aspect of male sexual dysfunction (interest, performance, and orgasm) and their implications for treatment. The authors address a wide variety of clinical issues, ranging from common medical risk factors for ED to the evaluation and management of men who have atypical presentations that require focused testing; from diabetic ED to the safety assessment of PDE inhibitors for cardiac patients; and from combination drug therapy for refractory patients to neuropharmacological therapies. Guidance is also provided for vacuum erection devices and surgical implants, the role of self-medication with dietary supplements, the management of post-prostatectomy ED, and the emerging pharmaceutical therapies for rapid ejaculation. On the pharmaceutical side, the authors summarize the pharmacology and development of PDE-type 5 inhibitors, review the preclinical data and 5 years of postmarketing data on Viagra®, examine the preclinical data on Levitra®, and discuss the design and conduct of US clinical trials of Cialis®. Authoritative and informative, Oral Pharmacotherapy for Male Sexual Dysfunction: A Guide to Clinical Management clarifies for urologists, family physicians, and internists each of the diagnostic approaches to male sexual dysfunction, as well as the pharmacological strategies available for its safe and effective management. Doody Review Services Reviewer:Allen D. Seftel, MD(Case Western Reserve University)Description:This short book primarily covers male sexual function, although there is one chapter devoted to female sexual dysfunction. It is geared predominantly toward the oral PDE5 inhibitor drugs. Each of the 19 chapters is authored by an authority in the field and each covers a unique aspect of sexual function, including hypogonadism, rapid ejaculation, lifestyle issues and dietary supplements, and oral therapies. There is a focus on the primary care clinician as well. An adequate numbers of tables, graphs, and charts accompany the text.Purpose:The purpose is to familiarize clinicians with the latest developments in sexual function, including the oral PDE5 inhibitor drugs. The book meets these worthy objectives.Audience:It is written for practicing clinicians. It may be too advanced for medical students or novices. All the authors are credible authorities in their fields.Features:This book covers oral, topical, intraurethral and other therapies for male ED, although there is a focus on the oral PDE5 inhibitors, with attention paid to the physiology and mechanisms of these drugs. There is one chapter on female sexual dysfunction, several chapters devoted to the PCP, one chapter on herbal remedies, one chapter on diabetes, one chapter on cardiac disease, one chapter on epidemiology and one chapter on antidepressants. New data on this topic is published on a seemingly daily basis, making this book a bit dated. Nonetheless, the data are well presented, and this is a useful reference.Assessment:There are only a handful of books in this field, making any new one welcome. The few books in this field are all useful and generally well done, with limited overlap amongst all the books. This one is helpful for it reviews certain, specific aspects of sexuality that may not be fully covered in other books.
1Physiology and pharmacology of erectile dysfunction12Epidemiology of erectile dysfunction253Pharmacology of phosphodiesterase inhibitors434Sildenafil citrate, the classical PDE5 inhibitor : a five-year review of its efficacy and safety in the arena of erectile dysfunction655Tadalafil : clinical trials experience856Vardenafil : clinical trials experience1097Erectile dysfunction assessment and management in primary care practice1498When to refer the patient with erectile dysfunction to a specialist1859Erectile dysfunction : assessing risk and managing the cardiac patient19910Is diabetic erectile dysfunction more difficult to treat?22111Depression and antidepressant-associated erectile dysfunction23712Intracavernous, transurethral, and topical therapies for erectile dysfunction in the era of oral pharmacotherapy : salvaging first-line therapy failures with combination therapies25313Androgen deficiency of the aging male : enhancing erectile response to oral pharmacotherapy27914Central activation of erection and clinical experience30115Sustaining the cure : oral pharmacotherapy failures salvage with vacuum devices and penile implants32316Prevention and treatment of erectile dysfunction utilizing lifestyle changes and dietary supplements : what works and what is worthless?33917Pharmacological strategies in the management of rapid ejaculation37918Sexual dysfunction after radical prostatectomy and the use of PDE-5 inhibitors40919Female sexual dysfunction : is there a magic pill?423
