Physiology of the Heart
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Dr. Arnold Katz's internationally acclaimed classic is now in its thoroughly revised Fourth Edition, incorporating the latest molecular biology research and extensively exploring the clinical applications of these findings. In a readable style enhanced by more than 400 diagrams, Dr. Katz provides a comprehensive overview of the physiological and biophysical basis of cardiac function, beginning with structure and proceeding to biochemistry, biophysics, and pathophysiology in arrhythmias, ischemia, and heart failure. This edition features a new clinical applications section and expanded chapters on the ischemic heart and heart failure. Doody Review Services Reviewer:Keith G Hickey, MD, BS(Ochsner Clinic Foundation)Description:The first half of this remarkable single-authored textbook provides a detailed examination of the cellular, molecular and genetic processes involved in the physiology of the normal and diseased heart. The second half explains how these processes affect the function of heart as an entire organ, both in health and disease.Purpose:This book presents the current understanding of the physiological and biophysical basis of cardiac function. This fourth edition examines both functional and proliferative signaling in great detail. In the last five years, abnormal proliferative signaling has emerged both as a major cause of heart disease and as a target for therapy.Audience:Although written for students, residents, and clinicians, the book can also benefit basic scientists to relate a special area of research to the overall physiology of the heart. The goal is to help healthcare providers learn more about basic sciences, and basic scientists to learn more about how the heart works in health and disease.Features:This book is divided into four parts. Part I reviews the structure, biochemistry, and biophysics of the normal heart. Part II contains three chapters covering regulation. Part III integrates the first two in describing the normal heart as a pump, and the electrical systems that control its beating. Lastly, part IV describes the pathophysiology of the three major types of heart disease, beginning with a review of the electrocardiogram and concluding with discussions of arrhythmias, ischemic heart disease, and heart failure.Assessment:This fourth edition provides exactly what the author intended, a simple approach to complex issues intended to explain concepts to students, physicians, and scientists alike. Only Dr. Katz, with 40 to 50 years of experience as both a basic scientist and a clinical cardiologist, as well as a gifted teacher, could have completed this undertaking. He has dedicated his life to cardiac physiology, and this edition of his now classic text is the best yet.
1Structure of the heart and cardiac muscle32Energetics and energy production403Energy utilization (work and heat)824The contractile proteins1035The cytoskeleton1276Active state, length-tension relationship, and cardiac mechanics1407Excitation-contraction coupling : extracellular and intracellular calcium cycles1628Signal transduction : functional signaling2039Signal transduction : proliferative signaling24510Regulation of cardiac muscle performance : functional and proliferative mechanisms28211The heart as a muscular pump31712The working heart33713Cardiac ion channels37014The cardiac action potential39115The electrocardiogram42716Arrhythmias46217The ischemic heart52218Heart failure546
