Safety of Nanoparticles: From Manufacturing to Medical Applications
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In spite of the potential use of nanomaterials as tissue engineering devices, implants, biosensors, drug delivery devices, etc., there has yet to be a compilation of the risks associated with the in vivo use of nanomaterials. There are numerous and well-known risks because of the size of nanoparticles. For example, nanoparticles can cross cell membranes and enter the cytoplasm undetected.The aim of this book is to provide one of the first (if not the first) detailed views of how cells and tissues in the body deal with nanoparticles. This is important not only for implantable devices, but also for the manufacturing of nanophase materials when particles can be inhaled or enter the body through the skin. Only by compiling research at the intersection of nanoparticles and biological processes can we determine if nanophase materials are safe to be manufactured, handled, and/or implanted for various medical applications.
1 Developing Practices for Safe Handling of Nanoparticles and Nanomaterials in a Development-Stage Enterprise: A Practical Guide for Research and Development Organizations Robert A. Hoerr Anand Gupta Michael J. Matuszewski 12 Cytotoxicity of Photoactive Naoparticles Yuhui Jin Xiaojun Zhao 193 Breeching Epithelial Barriers-Physiochemical Factors Impacting Nanomaterial Translocation and Toxicity Lisa DeLouise Luke Mortensen Alison Elder 334 Safety and Efficacy of Nano/Micro Materials Xiaohong Wei Yong-kyu Lee Kang Moo Huh Sungwon Kim Kinam Park 635 Biomedical Applications of Nanoparticles G.L. Prasad 896 Unexpected Reactions by In Vivo Applications of PEGylated Liposomes Tatsuhiro Ishida Hiroshi Kiwada 1117 Hydrogel Nanocomposites: Biomedical Applications, Biocompatibility, and Toxicity Analysis Samantha A. Meenach Kimberly W. Anderson J. Zach Hilt 1318 Cytotoxicity and Genotoxicity of Carbon Nanomaterials Amanda M. Schrand Jay Johnson Liming Dai Saber M. Hussain John J. Schlager Lin Zhu Yiling Hong Eiji Osawa 1599 Calcium Phosphate Nanoparticles: Toxicology and Lymph Node Targeting for Cancer Metastasis Prevention Rajesh A. Pareta 18910 Nanoparticles for Cancer Diagnosis and Therapy Andrew Z. Wang Frank X. Gu Omid C. Farokhzad 209Index 237
