Signal Transduction and the Gasotransmitters
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Focusing on the signal transduction mechanisms underlying gasotransmitters, the 22 contributions in this collection examine the endogenous production and physiological function of nitric oxide, carbon monoxide, and hydrogen sulfide, which share common chemical features and biological action modes, but differ from classical neurotransmitters and humoral factors. Primarily divided into three sections, each opening chapter describes the synthesis and metabolism of a particular gas. Other topics discussed include the chemical interaction of nitric oxide with protein thiols, S-nitrosylation of cyclic nucleotide-gated channels, the modulation of ion channels by carbon monoxide in nonvascular tissues, and the role of hydrogen sulfide as an endogenous vasorelaxant factor. Annotation © 2004 Book News, Inc., Portland, OR Doody Review Services Reviewer:Eugene A Davidson, PhD(Georgetown University School of Medicine)Description:This book offers a set of articles about the signaling properties of several gaseous molecules. Nitric oxide is well known; the others generally less familiar.Purpose:The goal is to provide a comprehensive review of the state of research in the area of gaseous signaling molecules. Given the wide ranging activities of these modulators, this is an important contribution. The coverage is thorough and goals well met.Audience:The target audience will include investigators, research fellows, and faculty responsible for teaching in this area. The editor is a recognized authority and has assembled a strong group of authors.Features:The recognition of nitric oxide as a molecule with regulatory roles changed the view of many with regard to signaling pathways. This book reviews the properties of that molecule (biosynthesis, chemical properties, signaling targets) as well as two close cousins -- carbon monoxide and hydrogen sulfide. It is noteworthy that the latter two species have been generally regarded as highly toxic (they are) and among the least likely candidates for normal cellular roles. Most of the actions of these "gasotransmitters" center on ion channels -- sodium, potassium and calcium -- and clearly have potentially major effects on their targets. An important issue relates to the mechanism of action of each, including the potential for direct chemical modification (nitrosylation, for example) of proteins. The initial chapters provide an overview of the field of gaseous signaling; these are followed by major sections devoted to each of the three. The accompanying bibliographies for each chapter are extensive and provide ample reference to original sources. Laboratories working in almost any area of signal transduction will want to have information regarding this new class of cellular second messengers -- a need well served by this book.Assessment:Although I was aware of the role of nitric oxide, I was unfamiliar with the role of the other molecules covered in this book. I found this to be an important contribution and it is worthwhile reading for most cell biologists and those studying regulation of cellular activities.
Pt. IGasotransmitters : past, present, and future1The evolution of gasotransmitter biology and medicine : from atmospheric toxic gases to endogenous gaseous signaling molecules32Interactions between gasotransmitters33Pt. IIThe emergence of the first gasotransmitter : nitric oxide3Nitric oxide : synthesis and metabolism, tissue stores, and the relationship of endothelium-derived nitric oxide to endothelium-dependent hyperpolarization594Chemical interaction of nitric oxide with protein thiols : S-nitrosylation signaling955Nitric oxide and adenosine triphosphate-sensitive potassium channels : their different properties but analogous effects on cellular protection1096Interactions of nitric oxide and related radical species with K[subscript Ca] channels1237Nitric oxide and voltage-gated Ca[superscript 2+] channels1378Interactions of nitric oxide and cardiac ion channels1579S-nitrosylation of cyclic nucleotide-gated channels169Pt. IIIStory of a silent killer : the resurgence of carbon monoxide as the second gasotransmitter10Synthesis and metabolism of carbon monoxide18711Interaction of carbon monoxide with K[superscript +] channels in vascular smooth muscle cells20512Modulation of multiple types of ion channels by carbon monoxide in nonvascular tissues and cells21913The molecular mechanisms underlying the effects of carbon monoxide on calcium-activated K[superscript +] channels23114Carbon monoxide and signal transduction pathways24915Carbon monoxide-induced alterations in the expression of K[subscript Ca] channels in pulmonary artery smooth muscle cells259Pt. IVGas of the rotten egg : hydrogen sulfide as the third gasotransmitter16Hydrogen sulfide production and metabolism in mammalian tissues27517Toxicological and environmental impacts of hydrogen sulfide29318Hydrogen sulfide and the regulation of neuronal activities31519The role of hydrogen sulfide as an endogenous vasorelaxant factor32320Hydrogen sulfide and visceral smooth muscle contractility33321Interaction of hydrogen sulfide and adenosine triphosphate-sensitive345Pt. VGasotransmitters, other gaseous molecules, and cell metabolism22Gasotransmitters as a novel class of metabolic regulators : nitric oxide, carbon monoxide, and nitrous oxide359
