Structure, Function, and Modulation of Neuronal Voltage-Gated Ion Channels
This book discusses voltage-gated ion channels and their importance in drug discovery and development. The book includes reviews of the channel genome, the physiological bases of targeting ion channels in disease, the unique technologies developed for ion channel drug discovery, and the increasingly important role of ion channel screening in cardiac risk assessment. It provides an important reference for research scientists and drug discovery companies.
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New promising tools for drug development and discovery researchers This contributed work features state-of-the-science reviews of the structure, function, and modulation of neuronal voltage-gated ion channels, with an emphasis on their new and emerging applications to drug discovery and development. The reviews, written by leading experts in the field, are either comprehensive reviews of particular voltage-gated ion channel members or in-depth reviews of topics relevant to multiple voltage-gated ion channel subfamilies. Structure, Function, and Modulation of Neuronal Voltage-Gated Ion Channels is divided into three logical sections: Section One: Neuronal Voltage-Gated Ion Channel Functions Section Two: Modulatory Mechanisms and Influences on Neuronal Voltage-Gated Ion Channel Function Section Three: Drug Discovery Targets and Technology Among the key topics addressed are: Biochemical and molecular mechanisms and pathways in neuronal voltage-gated ion channel regulation Physiological bases of targeting ion channels in disease Advances in screening technologies, and methods for regulating neuronal voltage-gated ion channels Custom-developed technologies for ion channel drug discovery Utility of neuronal voltage-gated ion channel targets for the development of new medicines in traditional and emerging therapeutic areas Collectively, this book's reviews provide students and researchers with many new tools and approaches for their current ion channel and drug discovery research. Moreover, the book points the direction to promising areas of investigation worthy of further study.
Pt. I Neuronal Voltage-Gated Ion Channel Functions 11 Neuronal L-Type Voltage-Gated Calcium Channels Alexander Scriabine Scriabine, Alexander David J. Triggle Triggle, David J. 32 Voltage-Gated N-Type and T-Type Calcium Channels and Excitability Disorders Elizabeth Tringham Tringham, Elizabeth Terrance P. Snutch Snutch, Terrance P. 353 Voltage-Gated Sodium Channels: Multiple Roles in the Pathophysiology of Pain Sulayman D. Dib-Hajj Dib-Hajj, Sulayman D. Bryan C. Hains Hains, Bryan C. Joel A. Black Black, Joel A. Stephen G. Waxman Waxman, Stephen G. 674 The Role of Ion Channels in the Etiology and Development of Gliomas Amy K. Weaver Weaver, Amy K. Harald Sontheimer Sontheimer, Harald 1055 Shaker Family K[subscript v]1 Voltage-Gated Potassium Channels in Mammalian Brain Neurons Helene Vacher Vacher, Helene James S. Trimmer Trimmer, James S. 1276 Unique Mitochondrial Ion Channels: Roles in Synaptic Transmission and Programmed Cell Death Elizabeth A. Jonas Jonas, Elizabeth A. 1557 Regulation of Neuronal Excitability by the Sodium-Activated Potassium Channels Slick (SLO2.1) and Slack (SLO2.2) Volentin K. Gribkoff Gribkoff, Volentin K. Leonard K. Kaczmarek Kaczmarek, Leonard K. 193Pt. II Modulatory Mechanisms and Influences on Neuronal Voltage-Gated Ion Channel Function 2178 Alternative Splicing of Neuronal Ca[subscript v]2 Calcium Channels Daine Lipscombe Lipscombe, Daine Summer E. Allen Allen, Summer E. Annette C. Gray Gray, Annette C. Spiro Marangoudakis Marangoudakis, Spiro Jesica Raingo Raingo, Jesica 2199 Effect of Hypoxia/Ischemia on Voltage-Dependent Channels Xiang Q. Gu Xiang, Q. Gu Hang Yao Hang, Yao Gabriel G. Haddad Haddad, Gabriel G. 25110In Vivo Roles of Ion Channel Regulatory Protein Complexes in Neuronal Physiology and Behavior Smith Reddy Reddy, Smith Mohammad Shahidullah Shahidullah, Mohammad Irwin B. Levitan Levitan, Irwin B. 27911 Regulation of Neuronal Ion Channels by G-Protein-Coupled Receptors in Sympathetic Neurons Mark S. Shapiro Shapiro, Mark S. Nikita Gamper Gamper, Nikita 29112 BK Channels: Regulation of Expression and Physiological Impact Pallob Kundu Kundu, Pallob Abderrahmane Alioua Alioua, Abderrahmane Yogesh Kumar Kumar, Yogesh Rong Lu Rong, Lu Jimmy W. Ou Ou, Jimmy W. Enrique Sanchez-Pastor Sanchez-Pastor, Enrique Min Li Min, Li Enrico Stefani Stefani, Enrico Ligia Toro Toro, Ligia 31713 Structural Basis for Auxiliary KChIP Modulation of K[subscript v]4 Channels KeWei Wang Wang, KeWei Jijie Chai Chai, Jijie 343Pt. III Drug Discovery Targets and Technology 36314 Sodium Channel Blockers for the Treatment of Chronic Pain Mark R. Bowlby Bowlby, Mark R. Edward Kaftan Kaftan, Edward 36515 Neuronal K[subscript v]7 Potassium Channels as Emerging Targets for the Treatment of Pain Steven I. Dworetzky Dworetzky, Steven I. Valentin K. Gribkoff Gribkoff, Valentin K. 39316 Small-Molecule Modulators of Large-Conductance, Calcium-Activated (BK) Channels John E. Starrett, Jr. Starrett, John E., Jr. 42317 High-Throughput Screening Technologies in Ion Channel Drug Discovery Edward B. Stevens Stevens, Edward B. Andrew D. Whyment Whyment, Andrew D. J. Mark Treherne Treherne, J. Mark 443Index 467
