Targeted Cancer Therapy: A Handbook for Nurses
Targeted Cancer Therapy: A Handbook for Nurses is an essential guide for nurses interested in the latest discoveries in oncology. Covering the most recent treatment option of transforming cancer into a chronic illness, Targeted Cancer Therapy provides nurses with the information they need to understand this and future developments in the field. This comprehensive but easy-to-understand text takes nurses through foundational concepts in cell and normal biology that are crucial to understanding...
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Targeted Cancer Therapy: A Handbook For Nurses Is An Essential Guide For Nurses Interested In The Latest Discoveries In Oncology. Covering The Most Recent Treatment Option Of Transforming Cancer Into A Chronic Illness, Targeted Cancer Therapy Provides Nurses With The Information They Need To Understand This And Future Developments In The Field. This Comprehensive But Easy-To-Understand Text Takes Nurses Through Foundational Concepts In Cell And Normal Biology That Are Crucial To Understanding Cancer And Targeted Therapy. Featuring Relevant Analogies And Easy-To-Follow Discussions On Malignant Transformation, Metastases, Cellular Pathways, And Toxicities, This One-Of-A-Kind Text Enables Nurses To Quickly Get Up To Speed On Key Topics And Develop Care Plans For Oncology Patients. Accessible, Comprehensive, Informative, Targeted Cancer Therapy Is A Must-Read For Every Oncology Nurse. Doody Review Services Reviewer:Margaret R Hurst, BSN(University of New Mexico Hospital)Description:This book reviews all the major targeted therapies currently used to treat patients with cancer. Purpose:The purpose, as noted in the introduction, is to further educate nurses who work with targeted cancer therapies on how these drugs work in the context of the emerging knowledge in the field. This book is needed to help nurses understand how these medications work and how to manage side effects. Audience:Nurses working with cancer patients are the intended audience. The author is an oncology clinical instructor.Features:The book covers all the major classes of targeted therapy from how they work to how to manage their side effects. It is extremely thorough and includes a useful glossary in the back. However, it presumes a level of knowledge of cell and molecular biology that many nurses do not have. It may be more useful for nurses who work in advanced practice roles who may have a more in-depth knowledge of biology. Assessment:This is a good quality book, but it may be more suitable for advanced practice nurses than for most nurses currently working at the bedside. The subject is important, but the author seems to assume readers have a certain baseline knowledge that I do not believe many nurses working with these patients have.
Introduction vChapter 1 Cancer Biology, Signaling Pathways, and Malignant Transformation 1Hallmarks of Cancer 1Application of the Hallmarks of Cancer 2Invasion and Metastasis 18Epigenetics 30Summary 34References 34Chapter 2 Targeted Cancer Therapy: External and Internal Signaling Pathway Targets 39Monoclonal Antibodies 42Membrane-Bound Receptor Kinases (e.g., EGFR, HER2, HGF/c-Met, IGFR pathways) 73Hepatocyte Growth Factor (HGF/c-Met) Receptor Pathway Targets 125Insulin-like Growth Factor Receptor Pathway Targets 127Intracellular Signaling Kinases (e.g., src, P13k/Akt/mTOR; MAPK; sonic hedgehog pathways) 128Protein Kinase Signaling Pathways 129Protein Kinase Inhibitors 136Protein Dynamics: Heat Shock Proteins and Ubiquitin-Proteasome Inhibitors 150Epigenetic Abnormalities (DNA Methyltransferase and Histone Deacetylase) 160Tumor Vasculature and Microenvironment 175References 175Chapter 3 Tumor Vasculature 185Targeting Angiogenesis 185Antiangiogenic Drug Therapy 194Hypoxia-Inducible Factor, mTOR, and Angiogenesis 198Nursing Considerations and Drug Information 203References 250Chapter 4 Targeting the Microenvironment: Bone Metastasis, Apoptosis, DNA Repair, and Mitosis 255Bone Metastasis 255Pharmacologic Management 262Targeting Apoptosis 271DNA Repair Gene Mutations: Opportunities from Synthetic Lethality 277Mitotic Kinase Inhibitors 280Summary 284References 284Chapter 5 Challenges in Caring for Patients Receiving Targeted Therapy 289Drag Interactions: Focus on the P450 Microenzyme System 289Encouraging Patient Adherence and Persistence 302References 310Glossary 313Index 329
\ From The CriticsReviewer: Margaret R Hurst, BSN(University of New Mexico Hospital)\ Description: This book reviews all the major targeted therapies currently used to treat patients with cancer. \ Purpose: The purpose, as noted in the introduction, is to further educate nurses who work with targeted cancer therapies on how these drugs work in the context of the emerging knowledge in the field. This book is needed to help nurses understand how these medications work and how to manage side effects. \ Audience: Nurses working with cancer patients are the intended audience. The author is an oncology clinical instructor.\ Features: The book covers all the major classes of targeted therapy from how they work to how to manage their side effects. It is extremely thorough and includes a useful glossary in the back. However, it presumes a level of knowledge of cell and molecular biology that many nurses do not have. It may be more useful for nurses who work in advanced practice roles who may have a more in-depth knowledge of biology. \ Assessment: This is a good quality book, but it may be more suitable for advanced practice nurses than for most nurses currently working at the bedside. The subject is important, but the author seems to assume readers have a certain baseline knowledge that I do not believe many nurses working with these patients have.\ \ \ \ \ From The CriticsReviewer: Margaret R Hurst, BSN(University of New Mexico Hospital) \ Description: This book reviews all the major targeted therapies currently used to treat patients with cancer. \ Purpose: The purpose, as noted in the introduction, is to further educate nurses who work with targeted cancer therapies on how these drugs work in the context of the emerging knowledge in the field. This book is needed to help nurses understand how these medications work and how to manage side effects. \ Audience: Nurses working with cancer patients are the intended audience. The author is an oncology clinical instructor.\ Features: The book covers all the major classes of targeted therapy from how they work to how to manage their side effects. It is extremely thorough and includes a useful glossary in the back. However, it presumes a level of knowledge of cell and molecular biology that many nurses do not have. It may be more useful for nurses who work in advanced practice roles who may have a more in-depth knowledge of biology. \ Assessment: This is a good quality book, but it may be more suitable for advanced practice nurses than for most nurses currently working at the bedside. The subject is important, but the author seems to assume readers have a certain baseline knowledge that I do not believe many nurses working with these patients have.\ \
