The Metabolism Of Drugs And Other Xenobiotics, Vol. 1
Surpassing the 1976 book by Testa and Jenner, Drug Metabolism: Chemical and Biochemical Aspects (Dekker), this informative, up-to-date text includes the following features, unavailable elsewhere: First in a set of books to provide a comprehensive coverage of drug metabolism; Opening chapter provides a general introduction to the complete set of books; Other chapters cover reaction mechanisms, catalytic cycles, regio- and stereoselectivities, types of substrates, reactivity of intermediates,...
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In the present volume, the first in the Series The Metabolism of Drugs and Other Xenobiotics, Professor Testa discusses the molecular and biochemical aspects of reactions of oxidation and reduction. While an encyclopaedic treatment is avoided, the covered topics include biochemical properties of the enzymes/isoenzymes, drug-enzyme interactions, the various chemical reactions catalyzed by the enzyme (s), reaction mechanisms and catalytic cycles, regio- and stereoselectivities, structure-metabolism relationships, the reactivity of metabolic intermediates and molecular aspects of toxication and detoxication, as well as molecular mechanisms of direct and indirect enzyme inhibition. The classification of matters is based firstly on enzymes and their reactions, and secondly on the types of target groups being transformed, with carefully selected examples illustrating the reactions under discussion. Such a treatment has heuristic value since it renders the reader capable of educated guesses on the metabolism of other or novel drugs. Forthcoming volumes in the Series will present reactions of hydration and conjugation, and the biological regulations and consequences of xenobiotic metabolism.
Introduction: Xenobiotic Metabolism: The Global View (A General Introduction to the Series)1Ch. 1Xenobiotic Metabolism: The Biochemical View14Ch. 2Dehydrogenation of Alcohols and Aldehydes, Carbonyl Reduction41Ch. 3The Nature and Functioning of Cytochromes P450 and Flavin-containing-monooxygenases70Ch. 4Carbon Oxidations Catalyzed by Cytochromes P450122Ch. 5Monooxygenase-catalyzed Nitrogen Oxidations164Ch. 6Monooxygenase-catalyzed N-C Cleavage203Ch. 7Monooxygenase-catalyzed Oxidation of Oxygen- and Sulfur-Containing Compounds235Ch. 8Oxidative Dehalogenation, and Dealkylation of Organometallics284Ch. 9Oxidations Catalyzed by Various Oxidases and Monooxygenases298Ch. 10Reactions Catalyzed by Peroxidases346Ch. 11Oxidation of Mercury, Silicon, Phosphorus, Arsenic, Selenium and Halogens389Ch. 12Reductions Catalyzed by Cytochrome P450 and Other Oxidoreductases398Ch. 13Various Enzymatic and Non-enzymatic Reactions448Ch. 14Conclusion and Outlook460Index463
\ From the Publisher"What I really like and what I would like to emphasize is the fact that this book is not only a comprehensive collection of biochemical data on redox mechanisms, but is legible as well. The personal style and the commitment of the author that can be felt between the lines contributes to my unreserved recommendation to have this book on the shelf of everyone who is busy in the field of making compounds that interact with living systems."\ --Pharmaceutica Acta Helvetiae\ "Testa's deep comprehension of his subject and his scholarly commitment make sure that this volume is not only comprehensive but eminently readable."\ --SIR JAMES BLACK, Nobel Laureate\ "...several books have appeared on the metabolism of xenobiotic compounds, but this new text, by one of the most respected researchers in the field, has set the benchmark for all that follow... indispensible to all serious students of drug metabolims, and a collection to treasure."\ --Laurence J. Kim, University of Surrey, in ISSX NEWSLETTER\ "The overall impression is one of a book that is extensively and well researched with the facts clearly laid out in a very readable style."\ --David Needham in BRITISH TOXICOLOGY SOCIETY NEWSLETTER\ "The book would be very applicable as a text or reference for graduate and advanced undergraduate courses in toxicology, drug metabolism, medicinal chemistry and pharmacy. Professor Testa has done a very admirable job of compiling and presenting material of the subject. The book is strongly recommended as a course text and general reference, and I look forward to seeing the remaining three volumes in the series."\ --F. Peter Guengerich in PHARMACEUTICAL NEWS\ \
