The Molecular Basis of Human Cancer: Genomic Instability and Molecular Mutation in Neoplastic Transformation
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In this text, international experts in basic and clinical science provide an account of the best current understanding of the genetics of cancer. The 24 contributions detail each of the known molecular mechanisms governing neoplastic transformation in the breast, prostate, lung, liver, colon, skin, and in the leukemias and lymphomas. They illuminate both recent developments and established concepts in epidemiology, molecular techniques, oncogenesis, and mutation mechanisms, as well as the chemical, viral, and physical mechanisms of cancer induction. They also consider the future directions of research, including the exploitation of molecular targets for developing anticancer drugs, gene therapy, and the appropriate use of molecular information in genetic counseling. Edited by Coleman (U. of North Carolina School of Medicine) and Tsongalis (Hartford Hospital). Annotation c. Book News, Inc., Portland, OR (booknews.com) Doody Review Services Reviewer:Hidayatullah G. Munshi, MD(Northwestern University)Description:This book provides current information on the molecular basis of tumorigenesis. The contributors are well known basic and clinical scientists, mainly from the United States.Purpose:The purpose is to provide an overview of unifying concepts that pertain to carcinogenesis and then to demonstrate how these concepts are integrated in particular cancers. Detailed mechanisms relating to cancer development are provided for the more common cancers including breast and prostate. Audience:The book is geared primarily to graduate and medical students, but it would also be useful to seasoned researchers as it provides a good overview of a number of important themes in carcinogenesis.Features:The book is divided into seven parts. The first five parts, which make up about half the book, provide an overview of the causes of human cancers and of pertinent themes in oncogenesis. Part six provides in-depth information on mechanisms governing cancer development in the breast, prostate, lung, liver, colon, skin, leukemias, and lymphomas. Part seven describes how the information in the earlier parts of the book can help in the diagnosis and treatment of cancers. It is an easy to read book with a number of good illustrations. It is also very well referenced, though the references are slightly outdated.Assessment:On the whole, this is a well-written and well-referenced book on the genetics of cancer. It does provide easy-to-read information on a number of important themes pertaining to carcinogenesis. Unfortunately, like many other such books, it is a little outdated. Overall, this book would be useful to those who are interested in getting an overview of the field of human carcinogenesis.
PrefaceDedicationContributorsPt. IIntroduction1Cancer Epidemiology: Incidence and Etiology of Human Neoplasms3Pt. IIEssential Concepts in Molecular Biology2Essential Concepts and Techniques in Molecular Biology25Pt. IIIMolecular Themes in Oncogenesis3Cancer Genes454Positive Mediators of Cell Proliferation in Neoplastic Transformation655Inactivation of Negative Growth Regulators During Neoplastic Transformation81Pt. IVMechanisms of Mutation6The Role of Genomic Instability in the Development of Human Cancer1157Chromosomes and Chromosomal Instability in Human Cancer1438Hereditary Cancer159Pt. VEtiology of Human Cancers9Evolution of Research in Cancer Etiology18910Cellular Responses to Chemical Carcinogens20311Physical Agents in Human Carcinogenesis22312Viral Mechanisms of Human Carcinogenesis233Pt. VIHuman Tumor Systems13The Molecular Biology of Colorectal Carcinoma: Importance of the Wg/Wnt Signal Transduction Pathway25114Molecular Genetic Alterations in Primary Hepatocellular Neoplasms: Hepatocellular Adenoma, Hepatocellular Carcinoma, and Hepatoblastoma26915The Molecular Basis of Breast Carcinogenesis34716The Molecular Basis of Prostate Carcinogenesis36517The Molecular Basis of Lung Carcinogenesis37918The Molecular Basis of Skin Carcinogenesis40719The Molecular Biology of Leukemias42720Molecular Genetic Applications to the Diagnosis of Non-Hodgkin's Lymphoma461Pt. VIIFuture Directions21Cancer Genetic Counseling47722Molecular Genetic Diagnosis of Inherited Cancer Predisposition49723Novel Molecular Targets for Cancer Drug Discovery52124Gene Therapy in the Treatment of Human Cancer541Index567
