Transgenic And Knockout Models Of Neuropsychiatric Disorders

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Author: Gene S. Fisch

ISBN-10: 1588295079

ISBN-13: 9781588295071

Category: Basic Sciences

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In this up-to-date survey and critical assessment of transgenic and knockout models in neuropsychiatry and behavior, a panel of leading researchers comprehensively assesses how and whether the genetic abnormalities produced from these models manifest the neuropsychiatric disorders to which they correspond. The authors focus on transgenic and knockout models of neurocognitive dysfunction and neuropsychiatric dysfunction. The discussion of neurobiological problems covers mental retardation, polyglutamate, and speech disorders, as well as disorders that involve cognitive, social, speech, and language dysfunction. The neuropsychiatric dysfunctions examined include psychosis and schizophrenia, anxiety, depression, and bipolar disorder.

1Transgenic and knockout models of psychiatric disorders : introduction, history, and assessment32Transgenic mouse models and human psychiatric disease253Transgenic and knockout mouse models : the problem of language454If only they could talk : genetic mouse models for psychiatric disorders695Spinocerebellar ataxia type 1 : lessons from modeling a movement disease in mice876Mouse models of hereditary mental retardation1017How can studies of animals help to uncover the roles of genes implicated in human speech and language disorders?1278Animal models of autism : proposed behavioral paradigms and biological studies1519Genetic mouse models of psychiatric disorders : advantages, limitations, and challenges17710Animal models of psychosis19311Animal models of anxiety : the ethological perspective22112Modeling human anxiety and depression in mutant mice23713Mutant mouse models of bipolar disorder : are there any?265