Using Mass Spectrometry for Drug Metabolism Studies
The first edition of this now classic work helped to establish mass spectrometry as the premier tool for drug metabolism studies. Completely rewritten from start to finish, Using Mass Spectrometry for Drug Metabolism Studies, Second Edition brings medicinal chemists and mass spectrometry professionals up to speed with the rapid advances in the field, the emergence of cutting-edge approaches, and ways to meet steadily increasing vendor demands. Written by international scientists who are...
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The first edition of this now classic work helped to establish mass spectrometry as the premier tool for drug metabolism studies. Completely rewritten from start to finish, Using Mass Spectrometry for Drug Metabolism Studies, Second Edition brings medicinal chemists and mass spectrometry professionals up to speed with the rapid advances in the field, the emergence of cutting-edge approaches, and ways to meet steadily increasing vendor demands. Written by international scientists who are experts in their respective disciplines, this state-of-the-art reference effectively encapsulates current mass spectrometry best practices.The stand-alone chapters cover various topics — from metabolite identification to fast chromatography with UPLC — and in a style that is understandable to experts and field newcomers alike. The second edition of this bestseller includes coverage of new instrumentation and software as well as a wealth of updated information on the latest findings surrounding biomarkers and metabolomics and new chapters on both UPLC and DESI/DART.With more than 180 illustrations and an eight-page color insert, this valuable reference explores multiple modern mass spectrometry techniques and strategies. It includes an excellent overview of the entire drug discovery process plus the latest developments on how mass spectrometry is used to support this endeavor.
Preface ixEditor xiContributors xiiiChapter 1 Strategies and Techniques for Bioanalytical Assays as Part of New Drug Discovery Walter A. Korfmacher 1Chapter 2 The Drug Discovery Process: From Molecules to Drugs Mike S. Lee Steven E. Klohr 33Chapter 3 PK Principles and PK/PD Applications Hong Mei Richard A. Morrison 59Chapter 4 Mass Spectrometry for In Vitro ADME Screening Inhou Chu 99Chapter 5 Metabolite Identification Strategies and Procedures Ragu Ramanathan S. Nilgün Çömezoglu W. Griffith Humphreys 127Chapter 6 Reactive Metabolite Screening and Covalent-Binding Assays Gérard Hopfgartner 205Chapter 7 Fast Metabolite Screening in a Discovery Setting Xiaoying Xu 229Chapter 8 Fast Chromatography with UPLC and Other Techniques Sam Wainhaus 255Chapter 9 Supercritical Fluid Chromatography-Mass Spectrometry Yunsheng Hsieh 277Chapter 10 Biomarkers of Efficacy and Toxicity: Discovery and Assay Joanna R. Pols 297Chapter 11 Imaging Mass Spectrometry for Small Molecules Fangbiao Li 333Chapter 12 MALDI IMS for Proteins and Biomarkers Michelle L. Reyzer Richard M. Caprioli 355Chapter 13 Ambient Ionization Methods and Their Early Applications in ADME Studies Jing-Tao Wu 377Chapter 14 Pharmaceutical Applications of Accelerator Mass Spectrometry Lan Gao Swapan Chowdhury 391Index 419
