Enzybiotics: Antibiotic Enzymes as Drugs and Therapeutics
Presents the latest research and applications for a new, promising approach to fighting infectious diseases\ Enzybiotics is a promising way of fighting bacterial or fungal infectious diseases by using viruses or viral-derived lysins. Drawing from the fields of medicinal chemistry, microbiology, genetics, and biochemistry, this book presents the state of the science in enzybiotics research, fully exploring its emerging therapeutic applications.\ The book begins with four chapters that review...
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Presents the latest research and applications for a new, promising approach to fighting infectious diseasesEnzybiotics is a promising way of fighting bacterial or fungal infectious diseases by using viruses or viral-derived lysins. Drawing from the fields of medicinal chemistry, microbiology, genetics, and biochemistry, this book presents the state of the science in enzybiotics research, fully exploring its emerging therapeutic applications.The book begins with four chapters that review the potential applications, possible advantages, and phylogeny of enzybiotics. Next, the book explores: A new approach to controlling infections using Gram-negative bacteriaBacteriophage holins and their membrane-disrupting activityAnti-staphylococcal lytic enzymesMembrane-targeted enzybioticsDesign of phage cocktails for therapy from a host-range point of viewNovel methods to identify new enzybioticsGenetically modified phages that deliver suicidal genes to target bacteriaThe authors, all active enzybiotics researchers, offer a variety of perspectives, the benefit of their own hands-on investigations, as well as a thorough review and analysis of the current literature.As more and more bacteria become resistant to antibiotics, the development of new disease-fighting agents has become essential. This book demonstrates the full potential of the emerging field of enzybiotics to control infectious diseases. Moreover, it will serve as a springboard for new research and the development of new therapeutics.
Preface viiContributors ix1 Enzybiotics and Their Potential Applications in Medicine Jan Borysowski Andrzej Górski 12 Advantages and Disadvantages in the Use of Antibiotics Or Phages As Therapeutic Agents Patricia Veiga-Crespo Tomas G. Villa 273 Enzybiotics as Selective Killers of Target Bacteria Juan C. Alonso Marcelo E. Tolmasky 594 Phylogeny of Enzybiotics Patricia Veiga-Crespo Tomas G. Villa 755 Bacteriophage Lysins: The Ultimate Enzybiotic Vincent A. Fischetti 1076 Bacteriophage Holins and their Membrane-Disrupting Activity María Gassest 1237 Anti-Staphylococcal Lytic Enzymes Jan Borysowski Andrzej Górski 1498 Membrane-Trageted Enzybiotics María Gasset 1739 Design of Phage Cocktails For Therapy From a Host Range Point of Veiw Lawrence D. Goodridge 19910 Identifying Phage Lytic Enzymes: Past, Present, and Future Jonathan E. Schmitz Raymond Schuch Vincent A. Fischetti 21911 Use of Genetically Modified Phages to Deliver Suicidal Genes to target Bacteria Lawrence D. Goodridge 253Concluding Remarks: The Future of Enzybiotics Patricia Veiga-Crespo Tomas G. Villa 269Index 279
