Biomimetic Nanoceramics in Clinical Use: From Materials to Applications
Recent developments in nanostructured materials have led to a shift in focus away from the replacement of tissues and towards regeneration. Nanoceramics with biomimetic properties have great potential in bone regeneration and new synthesis strategies have been developed to obtain materials with improved biocompatibility and multifunctional performance. The aim is to develop fully biocompatible implants, which exhibit biological responses at the nanometric scale in the same way that biogenic...
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Recent developments in nanostructured materials have led to a shift in focus away from the replacement of tissues and towards regeneration. Nanoceramics with biomimetic properties have great potential in bone regeneration and new synthesis strategies have been developed to obtain materials with improved biocompatibility and multifunctional performance. The aim is to fully develop biocompatible implants, which exhibit biological responses at the nanometric scale in the same way as biogenic materials. Current man-made implants are not fully biocompatible and always result in a foreign-body reaction involving inflammatory response and fibrous encapsulation. Great efforts have been made to develop synthetic strategies that tailor implant surfaces at the nanometric scale. The intention is to optimize the interaction at the tissue/implant interface, thus improving the quality of life for patients, with the enhanced results and shorter rehabilitation periods.
Ch. 1 Biological Apatites in Bone and Teeth1.1 Hard-Tissue Biomineralisation: How Nature Works 11.2 Alternatives to Obtain Nanosized Calcium-Deficient Carbonate-Hydroxy-Apatites 21References 23Ch. 2 Synthetic Nanoapatites2.1 Introduction 252.2 Synthesis Methods 28References 55Ch. 3 Biomimetic Nanoapatites on Bioceramics3.1 Introduction 613.2 Simulated Physiological Solutions for Biomimetic Procedures 663.3 Biomimetic Crystallisation Methods 703.4 Calcium Phosphate Bioceramics for Biomimetic Crystallisation of Nanoapatites. General Remarks 723.5 Biomimetic Nanoceramics on Hydroxyapatite and Advanced Apatite-Derived Bioceramics 803.6 Biphasic Calcium Phosphates (BCPs) 853.7 Biomimetic Nanoceramics on Bioactive Glasses 883.8 Biomimetism in Organic-Inorganic Hybrid Materials 105References 111Ch. 4 Clinical Applications of Apatite-Derived Nanoceramics4.1 Introduction 1224.2 Nanoceramics for Bone-Tissue Regeneration 1234.3 Nanocomposites for Bone-Grafting Applications 1294.4 Nanostructured Biomimetic Coatings 1404.5 Nanoapatites for Diagnosis and Drug/Gene-Delivery Systems 147References 154Subject Index 164
