Bioprocess Engineering Principles
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The emergence and refinement of techniques in molecular biology has changed our perceptions of medicine, agriculture, and environmental management. Scientific breakthroughs in gene expression, protein engineering, and cell fusion are being translated by a strengthening biotechnology industry into revolutionary new products and services. Many a student has been enticed by the promise of biotechnology and the excitement of being near the cutting edge of scientific advancement. However, graduates trained in molecular biology and cell manipulation soon realise that these techniques are only part of the picture. Reaping the full benefits of biotechnology requires manufacturing capability involving the large-scale processing of biological material. Increasingly, biotechnologists are being employed by companies to work in cooperation with chemical engineers to achieve pragmatic commercial goals. For many years, aspects of biochemistry and molecular genetics have been included in chemical engineering curricula, yet there has been little attempt until recently to teach aspects of engineering applicable to process design to biotechnologists.This textbook is the first to present the principles of bioprocess engineering in a way that is accessible to biological scientists. Other texts on bioprocess engineering currently available assume that the reader already has engineering training. On the other hand, chemical engineering textbooks do not consider examples from bioprocessing, and are written almost exclusively with the petroleum and chemical industries in mind. This publication explains process analysis from an engineering point of view, but refers exclusively to the treatment of biological systems. Over 170 problems and worked examples encompass a wide range of applications, including recombinant plant and animal cell cultures, immobilised catalysts, as well as traditional fermentation systems.
PrefaceCh. 1Bioprocess Development: An Interdisciplinary Challenge3Ch. 2Introduction to Engineering Calculations9Ch. 3Presentation and Analysis of Data27Ch. 4Material Balances51Ch. 5Energy Balances86Ch. 6Unsteady-State Material and Energy Balances110Ch. 7Fluid Flow and Mixing129Ch. 8Heat Transfer164Ch. 9Mass Transfer190Ch. 10Unit Operations218Ch. 11Homogeneous Reactions257Ch. 12Heterogeneous Reactions297Ch. 13Reactor Engineering333Appendices393Appendix A Conversion Factors395Appendix B Physical and Chemical Property Data398Appendix C Steam Tables408Appendix D Mathematical Rules413Appendix E List of Symbols417Index417
