Solid-State Fermentation Bioreactors
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This concise professional reference provides a fundamental framework for the design and operation of solid-state fermentation bioreactors, enabling researchers currently working at laboratory scale to scale-up their processes. After surveying the main bioreactor types currently used in solid-state fermentation, it focuses on the mathematical modeling of bioreactors, which is covered in three parts. Firstly, the book shows how to plan a research program in order to characterize the growth kinetics in a manner appropriate for incorporation into bioreactor models. Secondly, it addresses the heat and mass transfer phenomena that occur in solid-state fermentation bioreactors and the mathematical expressions that are used to describe them. Thirdly it demonstrates, through a number of case studies, how mathematical models can be used in the optimization of bioreactor performance. The final part of the book addresses several issues closely related with bioreactor operation, namely process monitoring equipment, process control strategies and the selection of an appropriate air preparation system.
1Solid-state fermentation bioreactor fundamentals : introduction and overview12The bioreactor step of SSF : a complex interaction of phenomena133Introduction to solid-state fermentation bioreactors334Heat and mass transfer in solid-state fermentation bioreactors : basic principles455The scale-up challenge for SSF bioreactors576Group I bioreactors : unaerated and unmixed657Group II bioreactors : forcefully-aerated bioreactors without mixing778Group III : rotating-drum and stirred-drum bioreactors959Group IVa : continuously-mixed, forcefully-aerated bioreactors11510Group IVb : intermittently-mixed forcefully-aerated bioreactors12911Continuous solid-state fermentation bioreactors14112Approaches to modeling SSF bioreactors15913Appropriate levels of complexity for modeling SSF bioreactors17914The kinetic sub-model of SSF bioreactor models : general considerations19115Growth kinetics in SSF systems : experimental approaches20716Basic features of the kinetic sub-model21917Modeling of the effects of growth on the local environment23518Modeling of heat and mass transfer in SSF bioreactors24919Substrate, air, and thermodynamic parameters for SSF bioreactor models26520Estimation of transfer coefficients for SSF bioreactors27921Bioreactor modeling case studies : overview29122A model of a well-mixed SSF bioreactor29523A model of a rotating-drum bioreactor31524Models of packed-bed bioreactors33125A model of an intermittently-mixed forcefully-aerated bioreactor34926Instrumentation for monitoring SSF bioreactors36327Fundamentals of process control37528Application of automatic control strategies to SSF bioreactors38729Design of the air preparation system for SSF bioreactors40330Future prospects for SSF bioreactors413AppGuide to the bioreactor programs
