Medicinal Protein Engineering
AnAll-Inclusive Review of the Achievements and Trends in the Fast-Growing Protein Engineering Field\ From humble beginnings like making fire for mere survival, engineering now steadfastly penetrates all aspects of our lives and even life itself at the molecular level. Protein engineering is a molecular biological discipline focused on designing and constructing novel proteins with desired properties. The currently limited understanding of the relationship between protein structure and...
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An All-Inclusive Review of the Achievements and Trends in the Fast-Growing Protein Engineering Field From humble beginnings like making fire for mere survival, engineering now steadfastly penetrates all aspects of our lives and even life itself at the molecular level. Protein engineering is a molecular biological discipline focused on designing and constructing novel proteins with desired properties. The currently limited understanding of the relationship between protein structure and function greatly hinders rational protein design. However, despite great challenges, protein engineering has become a major molecular discipline with a large array of successful applications to many complex medicinal problems.Medicinal Protein Engineering sheds light on this largely unchartered field, covering major strategies for engineering of proteins with predetermined biological properties. It discusses computational approaches to protein design and experimental approaches to protein construction. This volume also explores the tight connection between protein and genetic engineering. It moves researchers beyond experimental protein construction and theoretical protein design to the medicinal applications of engineered proteins.Examines Medicinal Applications of Protein Engineering for the Diagnosis, Treatment, and Prevention of DiseasesFocusing on the application of protein engineering to medicine, this seminal work outlines the appropriate techniques for studying protein properties and building mathematical engineering models of novel vaccines, diagnostic reagents, and therapeutic treatments. As a truly comprehensive assessment of the medical protein engineering research available and its future implications for disease control and prevention, this is an indispensable reference for biological researchers in this groundbreaking field.
Pt. I Computational ApproachesCh. 1 Web Resources for Protein Analysis Stephen A. Cammer Cammer, Stephen A. Michael Czar Czar, Michael 3Ch. 2 Artificial Neural Networks for Therapeutic Protein Engineering James Lara Lara, James 23Ch. 3 Phylogenetics and Medicinal Protein Engineering Michael Anthony Purdy Purdy, Michael Anthony 57Ch. 4 Clustering and Classification Approaches to Identifying Protein Properties Lilia Milkova Ganova-Raeva Ganova-Raeva, Lilia Milkova Zoya Emilova Dimitrova Dimitrova, Zoya Emilova 79Ch. 5 Analysis of Coordinated Substitutions in Proteins David Campo Campo, David 107Pt. II Protein Engineering Targets: VaccineCh. 6 Tuning the Immune Response to Our Advantage: Design of Vaccines with Tailored Functions Till A. Rohn Rohn, Till A. Martin F. Bachmann Bachmann, Martin F. 123Ch. 7 Modification of HIV-1 Envelope Glycoprotein to Enhance Immunogenicity Michael Aidoo Aidoo, Michael Salvatore Butera Butera, Salvatore Dennis Ellenberger Ellenberger, Dennis 143Ch. 8 Engineering Better Influenza Vaccines: Traditional and New Approaches Peter M. Pushko Pushko, Peter M. Rick A. Bright Bright, Rick A. Terrence M. Tumpey Tumpey, Terrence M. Gale E. Smith Smith, Gale E. 169Ch. 9 Construction of Novel Vaccines on the Basis of Virus-Like Particles: Hepatitis B Virus Proteins as Vaccine Carriers Paul Pumpens Pumpens, Paul Rainer G. Ulrich Ulrich, Rainer G. Kestutis Sasnauskas Sasnauskas, Kestutis Andris Kazaks Kazaks, Andris Velta Ose Ose, Velta Elmars Grens Grens, Elmars 205Ch. 10 Polyomavirus-Derived Virus-Like Particles Rainer G. Ulrich Ulrich, Rainer G. Alma Gedvilaite Gedvilaite, Alma Tatyana Voronkova Voronkova, Tatyana AndrisKazaks Kazaks, Andris Kestutis Sasnauskas Sasnauskas, Kestutis Reimar Johne Johne, Reimar 249Ch. 11 Papillomavirus-Derived Virus-Like Particles Andris Kazaks Kazaks, Andris Tatyana Voronkova Voronkova, Tatyana 277Ch. 12 Recombinant Vaccines Against Hepatitis Viruses Jonny Yokosawa Yokosawa, Jonny Nestor O. Perez Perez, Nestor O. Livia M. G. Rossi Rossi, Livia M. G. 299Pt. III Protein Engineering Targets: Diagnostics and TherapyCh. 13 Designer Diagnostic Reagents and Allergens Anna Obriadina Obriadina, Anna 319Ch. 14 Peptide-Based Diagnostic Assays Maria J. Gomara Gomara, Maria J. Isabel Haro Haro, Isabel 333Ch. 15 Recombinant Antibodies Alla Likhacheva Likhacheva, Alla Tatyana Ulanova Ulanova, Tatyana 353Ch. 16 Protein Engineering for HIV Therapeutics James M. Smith Smith, James M. Dennis Ellenberger Ellenberger, Dennis Salvatore Butera Butera, Salvatore 385Ch. 17 Recombinant Enzymes with New and Improved Properties Lilia M. Ganova-Raeva Ganova-Raeva, Lilia M. 407Pt. IV Special Expression SystemsCh. 18 Production of Pharmaceutical Compounds in Plants Miguel Angel Gomez Lim Lim, Miguel Angel Gomez 445Ch. 19 Plant Virus Biotechnology Platforms for Expression of Medicinal Proteins Andris Zeltins Zeltins, Andris 481Ch. 20 Alphaviruses: Multiplicity of Vectors and Their Promising Application as Vaccines and Cancer Therapy Agents Anna Zajakina Zajakina, Anna Baiba Niedre-Otomere Niedre-Otomere, Baiba Ekaterina Alekseeva Alekseeva, Ekaterina Tatyana Kozlovska Kozlovska, Tatyana 519Index 551
