Rational Design Of Stable Protein Formulations, Vol. 13
Recombinant proteins and polypeptides continue to be the most important class of biotechnology-derived agents in today's pharmaceutical industry. Over the past few years, our fundamental understanding of how proteins degrade and how stabilizing agents work has made it possible to approach formulation of protein pharmaceuticals from a much more rational point of view.\ This book describes the current level of understanding of protein instability and the strategies for stabilizing proteins...
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Recombinant proteins and polypeptides continue to be the most important class of biotechnology-derived agents in today's pharmaceutical industry. Over the past few years, our fundamental understanding of how proteins degrade and how stabilizing agents work has made it possible to approach formulation of protein pharmaceuticals from a much more rational point of view.This book describes the current level of understanding of protein instability and the strategies for stabilizing proteins under a variety of stressful conditions. Booknews Identifies the mechanisms underlying the degradation of proteins, and summarizes advances made in the formulation and stabilization of protein pharmaceuticals. The eight chapters present techniques for recombinant production of native proteins from escherichia coli, the physical stabilization of proteins in aqueous solution, and the rational design of stable lyophilized protein formulations. Other topics include spray-drying proteins, surfactant-protein interactions, and the effects of conformation on the chemical stability of pharmaceutically relevant polypeptides. Annotation c. Book News, Inc., Portland, OR (booknews.com)
Ch. 1Practical Approaches to Protein Formulation DevelopmentCh. 2Recombinant Production of Native Proteins from Escherichia coliCh. 3Physical Stabilization of Proteins in Aqueous SolutionCh. 4Effects of Conformation on the Chemical Stability of Pharmaceutically Relevant PolypeptidesCh. 5Rational Design of Stable Lyophilized Protein Formulations: Theory and PracticeCh. 6Spray-Drying of ProteinsCh. 7Surfactant-Protein InteractionsCh. 8High Throughout Formulation: Strategies for Rapid Development of Stable Protein ProductsIndex
\ From The CriticsIdentifies the mechanisms underlying the degradation of proteins, and summarizes advances made in the formulation and stabilization of protein pharmaceuticals. The eight chapters present techniques for recombinant production of native proteins from escherichia coli, the physical stabilization of proteins in aqueous solution, and the rational design of stable lyophilized protein formulations. Other topics include spray-drying proteins, surfactant-protein interactions, and the effects of conformation on the chemical stability of pharmaceutically relevant polypeptides. Annotation c. Book News, Inc., Portland, OR (booknews.com)\ \
